Secondary analysis (intention to treat population) after excluding fissures with one of five features of chronicity. Complete healing assessed after eight weeks of treatment with glyceryl trinitrate (GTN) or placebo
| Treatment group | Proportion healed (%) | 95% CI | p value v placebo |
|---|---|---|---|
| Using the Bonferroni method, p values were adjusted for multiple testing: χ2 test for trend, GTN versus placebo (χ2=4.5, p=0.03). | |||
| Only 145/181 ITT patients were available for this evaluation (in 36 patients “features of chronicity” were not completed by the investigator). | |||
| Placebo | 9/37 (24.3%) | 0.12–0.41 | |
| 0.1% GTN | 21/42 (50.0%) | 0.34–0.66 | 0.05 |
| 0.2% GTN | 13/36 (36.1%) | 0.21–0.54 | 0.91 |
| 0.4% GTN | 17/30 (56.7%) | 0.37–0.75 | 0.03 |