Percentages of patients with adverse events of interest for selective COX-2 inhibitors
| Placebo (n=221) | Rofecoxib 50 mg (n=219) | Naproxen 500 mg twice daily (n=220) | |
|---|---|---|---|
| Hypertension | 2.3 | 6.4 | 0.9 |
| Discontinued due to hypertension | 0.0 | 0.0 | 0.0 |
| Lower extremity oedema | 1.8 | 1.4 | 0.0 |
| Discontinued due to lower extremity oedema | 0.0 | 0.0 | 0.0 |
| Congestive heart failure | 0.0 | 0.5 | 0.0 |
| Discontinued due to congestive heart failure | 0.0 | 0.5 | 0.0 |
| Haemoglobin decreased | 1.4 | 3.7 | 5.5 |
| Haematocrit decreased | 2.3 | 4.1 | 7.8 |