Carrier and allele frequencies of the CARD15 gene variants R702W, G908R, and 1007fs in patients with Crohn’s disease (CD) or ulcerative colitis (UC) and in controls
| CARD15 genotype frequency | ||||
|---|---|---|---|---|
| Group | Homozygotes (n/(%)) | Heterozygotes (n/(%)) | Wt/Wt (n/(%)) | CARD15 variant allele frequency (%) |
| *1007fs allele frequencies, CD familial versus CD sporadic: p<0.01. | ||||
| †1007fs allele frequencies, CD all versus controls: p<0.01. | ||||
| Wt, wild-type allele. | ||||
| CD sporadic (n=198) | ||||
| R702W | 0/(0.0) | 13/(6.6) | 185/(93.4) | 3.3 |
| G908R | 0/(0.0) | 2/(1.0) | 196/(99.0) | 0.5 |
| 1007fs | 1/(0.5) | 12/(6.1) | 185/(93.4) | 3.5 |
| CD familial (n=46) | ||||
| R702W | 0/(0.0) | 3/(6.5) | 43/(93.5) | 3.3 |
| G908R | 0/(0.0) | 1/(2.2) | 45/(97.8) | 1.1 |
| 1007fs | 2/(4.4) | 6/(13.0) | 38/(82.6) | 10.9* |
| CD mixed families (n=27) | ||||
| R702W | 0/(0.0) | 2/(7.4) | 25/(92.6) | 3.7 |
| G908R | 0/(0.0) | 0/(0.0) | 27/(100.0) | 0.0 |
| 1007fs | 0/(0.0) | 2/(7.4) | 25/(92.6) | 3.7 |
| CD all (n=271) | ||||
| R702W | 0/(0.0) | 18/(6.6) | 253/(93.4) | 3.3 |
| G908R | 0/(0.0) | 3/(1.1) | 268/(98.9) | 0.6 |
| 1007fs | 3/(1.1) | 20/(7.4) | 248/(91.5) | 4.8† |
| UC (n=99) | ||||
| R702W | 0/(0.0) | 3/(3.0) | 96/(97.0) | 1.5 |
| G908R | 0/(0.0) | 0/(0.0) | 99/(100.0) | 0.0 |
| 1007fs | 0/(0.0) | 6/(6.1) | 93/(94.0) | 3.0 |
| Controls (n=300) | ||||
| R702W | 0/(0.0) | 11/(3.7) | 289/(96.3) | 1.8 |
| G908R | 0/(0.0) | 0/(0.0) | 300/(100.0) | 0.0 |
| 1007fs | 0/(0.0) | 10/(3.3) | 290/(96.7) | 1.7 |