Characteristics of patients with Crohn’s disease (CD) according to CARD15 gene status
| CARD15 status | |||
|---|---|---|---|
| Variable | Wt/Wt homozygotes (n=229) | Carriers of variants (n=42) | p Value |
| Wt, wild-type allele. | |||
| †Azathioprine, methotrexate, or cyclosporine. | |||
| Familial | 58 (25%) | 15 (36%) | NS |
| Pure disease/CD (n=46) | 35 | 11 | |
| Mixed (n=27) | 23 | 4 | |
| Men (%) | 99 (43%) | 20 (48%) | NS |
| Median (range) age at diagnosis (y) | 27.5 (9–65) | 26.8 (7–69) | NS |
| Median (range) duration (y) | 6.0 (0–46) | 12.3 (0.3–29) | <0.01 |
| Medication | |||
| 5-ASA | 222 (97%) | 38 (90%) | |
| Metronidazole | 144 (63%) | 24 (57%) | NS |
| Steroids | 172 (75%) | 31 (74%) | |
| Immunosuppressives† | 91 (40%) | 15 (36%) | |
| Bowel surgery (%) | 105 (46%) | 28 (67%) | <0.05 |
| Indication for surgery | |||
| Emergency | 5 | 3 | |
| Complication | 85 | 23 | |
| Chronic active disease | 15 | 1 | |
| Dysplasia/carcinoma | 0 | 1 | |
| Smoking | |||
| No | 73 (32%) | 16 (38%) | |
| Ex or casual | 36 (16%) | 7 (17%) | NS |
| Yes | 106 (46%) | 17 (40%) | |