Odds ratios (ORs) with 95% confidence intervals (CIs) for risk of adenoma occurrence by familial history of colorectal cancer (FHCRC) and other cancers (FHOC) in first degree relatives
| Hospital controls (n=35)* | Healthy controls (n=35)* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases n | n | Crude OR (95% CI) | Adjusted† OR (95% CI) | Adjusted‡ OR (95% CI) | Adjusted§ OR (95% CI) | n | Crude OR (95% CI) | Adjusted† OR (95% CI) | Adjusted‡ OR (95% CI) | Adjusted§ OR (95% CI) | |
| *Both sets of controls are sex (50% men) and age matched (±5 years) to the cases and proven to be free of polyps by colonoscopy. | |||||||||||
| †Adjusted for smoking status. | |||||||||||
| ‡Adjusted for smoking status and intake of alcohol (g/day). | |||||||||||
| §Adjusted: FHCRC for FHOC and FHOC for FHCRC. | |||||||||||
| FHCRC | |||||||||||
| No | 73 | 30 | 1.0 | 1.0 | 1.0 | 1.0 | 29 | 1.0 | 1.0 | 1.0 | 1.0 |
| Yes | 14 | 5 | 1.2 (0.4–3.5) | 1.2 (0.4–3.8) | 1.1 (0.3–3.5) | 1.1 (0.4–3.5) | 6 | 0.9 (0.3–2.7) | 0.9 (0.3–2.8) | 0.9 (0.3–2.8) | 0.9 (0.3–2.7) |
| FHOC | |||||||||||
| No | 50 | 24 | 1.0 | 1.0 | 1.0 | 1.0 | 23 | 1.0 | 1.0 | 1.0 | 1.0 |
| Yes | 37 | 11 | 1.6 (0.7–3.7) | 1.6 (0.7–3.7) | 1.6 (0.7–3.8) | 1.6 (0.7–3.7) | 12 | 1.4 (0.6–3.2) | 1.5 (0.6–3.5) | 1.5 (0.6–3.5) | 1.4 (0.6–3.2) |