Familial predisposition of colorectal cancer (FHCRC) and other types of cancers (FHOC) among first degree relatives and risk of net growth of adenomas <10 mm followed up in situ three years after inclusion
| Crude OR (95% CI) | Adjusted OR (95% CI)¶ | |||||||
|---|---|---|---|---|---|---|---|---|
| Cases with net adenoma growth* (n) | Cases with no net adenoma growth† (n) | All‡ | Placebo§ | All‡ | Placebo§ | Adjusted OR (95% CI)** (All‡) | Adjusted OR (95% CI)†† (All‡) | |
| *Net growth=more than 1 mm increase in total adenoma diameter after three years. | ||||||||
| †No net growth=less than 1 mm increase in total adenoma diameter after three years; no detectable change or regression. | ||||||||
| ‡Data for the whole study group of 87 adenoma cases | ||||||||
| §Data for the 48 adenoma cases who only received placebo during the three years of intervention.27 | ||||||||
| ¶Adjusted for smoking status. | ||||||||
| **Adjusted for type of intervention and smoking status. | ||||||||
| ††Adjusted for type of intervention and number of polyps found at inclusion. | ||||||||
| FHCRC | ||||||||
| No | 22‡/13d§ | 51‡/28§ | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Yes | 9/5 | 5/2 | 4.2 (1.3–13.9) | 5.4 (0.9–31.5) | 3.7 (1.1–12.5) | 4.3 (0.7–26.5) | 3.8 (1.1–12.8) | 3.9 (1.2–13.4) |
| FHOC | ||||||||
| No | 19/13 | 31/16 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Yes | 12/5 | 25/14 | 0.8 (0.3–1.9) | 0.4 (0.1–1.5) | 0.7 (0.3–1.8) | 0.3 (0.1–1.1) | 0.7 (0.3–1.8) | 0.9 (0.3–2.1) |