Regional variation in P-glycoprotein expression in humans and rodents
| Authors | Subjects | Methods | Findings |
|---|---|---|---|
| MDR, multidrug resistance; mRNA, messenger mRNA. | |||
| Yumoto19 | Mice | Efflux rate via rhodamine-123 assays | High in ileum compared with duodenum |
| Fojo18 | Human tissues | MDR1 mRNA | Colon>jejunum>rectum>stomach/oesophagus |
| Fricker17 | Human GI tract | MDR1 mRNA | Colon>jejunum/ileum>stomach |
| Chianale16 | Rat intestine | mdr3 mRNA and rhodamine-123 assay | Ileum>jejunum>duodenum |
| Trezise20 | Rat intestine | mdr3 mRNA | Moderate expression in duodenum/jejunum, maximal expression in ileum, and decreased expression from proximal to distal colon |