Table 1

Comparison of platelet depleted plasma 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) concentrations, and turnover, between female subjects with diarrhoea predominant irritable bowel syndrome (d-IBS) and healthy subjects

d-IBS (n=39)Healthy (n=20)Ratio d-IBS to healthyp Value
Results are adjusted geometric means (95% confidence interval).
AUC, ratio to fasting baseline area under the postprandial concentration/time curve.
5-HT concn
    Fasting (nmol/l)28.0025.451.10 (0.90,1.34)0.348
    Fed AUC1.731.511.15 (0.88,1.49)0.306
    Fed peak (nmol/l)76.1187.810.87 (0.59,1.27)0.458
5-HIAA concn
    Fasting (nmol/l)28.2427.201.04 (0.90,1.19)0.595
    Fed AUC1.401.191.18 (1.00,1.39)0.048
    Fed peak (nmol/l)53.5047.231.13 (0.87,1.48)0.350
Turnover (ratio 5-HIAA:5-HT)
    Fasting1.021.090.94 (0.85,1.05)0.260
    Fed AUC0.870.900.96 (0.86,1.08)0.512
Platelet 5-HT (nmol/109 platelets)
    Fasting2.251.831.23 (1.05,1.43)0.009