Comparison of platelet depleted plasma 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) concentrations, and turnover, between female subjects with diarrhoea predominant irritable bowel syndrome (d-IBS) and healthy subjects
| d-IBS (n=39) | Healthy (n=20) | Ratio d-IBS to healthy | p Value | |
|---|---|---|---|---|
| Results are adjusted geometric means (95% confidence interval). | ||||
| AUC, ratio to fasting baseline area under the postprandial concentration/time curve. | ||||
| 5-HT concn | ||||
| Fasting (nmol/l) | 28.00 | 25.45 | 1.10 (0.90,1.34) | 0.348 |
| Fed AUC | 1.73 | 1.51 | 1.15 (0.88,1.49) | 0.306 |
| Fed peak (nmol/l) | 76.11 | 87.81 | 0.87 (0.59,1.27) | 0.458 |
| 5-HIAA concn | ||||
| Fasting (nmol/l) | 28.24 | 27.20 | 1.04 (0.90,1.19) | 0.595 |
| Fed AUC | 1.40 | 1.19 | 1.18 (1.00,1.39) | 0.048 |
| Fed peak (nmol/l) | 53.50 | 47.23 | 1.13 (0.87,1.48) | 0.350 |
| Turnover (ratio 5-HIAA:5-HT) | ||||
| Fasting | 1.02 | 1.09 | 0.94 (0.85,1.05) | 0.260 |
| Fed AUC | 0.87 | 0.90 | 0.96 (0.86,1.08) | 0.512 |
| Platelet 5-HT (nmol/109 platelets) | ||||
| Fasting | 2.25 | 1.83 | 1.23 (1.05,1.43) | 0.009 |