Table 2

Comparison of platelet depleted plasma 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) concentrations, and turnover, between female subjects with diarrhoea predominant irritable bowel syndrome (d-IBS) with and without postprandial (pp) symptoms

With pp symptoms (n=31)Without pp symptoms (n=8)Ratio with to without pp symptomsp Value
Results are adjusted geometric means (95% confidence interval).
AUC, ratio to fasting baseline area under the postprandial concentration/time curve.
5-HT concn
    Fasting (nmol/l)29.2028.571.02 (0.81,1.30)0.851
    Fed AUC1.781.261.41 (0.97,2.05)0.069
    Fed peak (nmol/l)87.5954.581.61 (0.94,2.73)0.079
5-HIAA concn
    Fasting (nmol/l)28.8728.871.00 (0.84,1.19)0.989
    Fed AUC1.431.211.18 (0.93,1.49)0.161
    Fed peak (nmol/l)57.3244.771.28 (0.88,1.86)0.192
Turnover (ratio 5-HIAA:5-HT)
    Fasting1.001.020.98 (0.88,1.09)0.664
    Fed AUC0.861.010.85 (0.73,1.01)0.058
Platelet 5-HT (nmol/109 platelets)
    Fasting2.182.360.92 (0.76,1.13)0.416