Studies on the effects of corticosteroids on multidrug resistance/P-glycoprotein 170 expression
| Author | Subject | Dexamethasone treated | Effects |
|---|---|---|---|
| ↑,increased; ―,no change; ↓, decreased; | |||
| P-gp, P-glycoprotein 170. | |||
| Zhao14 | Mouse hepatoma cell line | Yes | ↑mdr1 and mdr3; ― mdr2 |
| Human hepatoma cell line | Yes | ↑MDR1 | |
| HeLa cell line | Yes | ―MDR1 | |
| Salphati39 | Rat liver | Yes | ↑mdr2 only in male rats; ―mdr1 and mdr3 in either sex |
| Lin40 | Rat liver and intestines | Yes | ↑P-gp both liver and intestines |
| Demeule41 | Rat organs | Yes | ↑P-gp in lungs and liver, ↓in kidneys, ?in intestines |
| Murakami42 | Rat intestines | Yes | ↑P-gp expression and function |
| Rat intestines (induced acute liver and renal failure) | No | ↑P-gp expression but ↓function | |