Table 4

Single nucleotide polymorphisms (SNPs) in the MDR1 gene

SNPRegionnHetrozygous (%)Homozygous (%)EstimatedEffect
The positions of the identified SNPs correspond to positions of the MDR1 cDNA (gb: M14758, codon TTC in exon 10) with the first base of the ATG start codon set to 1. SNPs that are located in introns are presented as exon +/−n, where n=nucleotide upstream (+) or downstream (−) of exons. The predicted ratios of homozygous genotypes (q2) was calculated on the basis of Hardy-Weinberg distribution.
T-12CExon 18511.8 0 0.4Non-coding
G-1AExon 218811.2 0 0.4Translation
A61GExon 218817.6 0.5 0.81Asn21Asp
G-25TIntron 48526.0 3.5 2.3Unknown
G-35CIntron 485 1.2 0 0.01Unknown
T307CExon 585 1.2 0 0.01Phe103Leu
C+139TIntron 58548.216.516.8Unknown
C+145TIntron 585 2.4 0 0.01Unknown
G1199AExon 118512.9 0 0.4Ser400Asn
C1236TExon 1218848.913.314.4Gly412Gly
C+44TIntron 1218811.7 0 0.4Unknown
T-76AIntron 168545.922.420.3Unknown
A+137GIntron 1785 1.2 0 0.01Unknown
G2677TExon 218343.442.238.4Ala893Ser
G2995AExon 243611.1 0Ala999Thr
C3435TExon 2653747.726.424.1Ile1145Ile
C3396TExon 26188 0.53 0 0.01Wobble