Study | Cell type | Expression/function MDR1 3435T | Plasma drug concentrations |
---|---|---|---|
Pgp, P-glycoprotein; MDR1*2 haplotype, G677T/C3435T; NA, not available, MDR, multidrug resistance; mRNA, messenger RNA. | |||
↓, decrease;↑, increase. | |||
Hoffmeyer47 | Enterocytes | ↓MDR1 mRNA | ↑Digoxin |
Fellay52 | Peripheral blood mononuclear cells | ↓MDR1 mRNA and Pgp expression | ↓Nelfinavir and efinarvir |
Kim51 | Transfected murine NIH-3T3 | ↑Pgp function in vitro for MDR1*2 haplotype | ↓Fexofenadine |
Hitzl53 | CD 56 natural killer cells | ↓MDR1 mRRNA and Pgp expression | NA |
Nakamura54 | Duodenal enterocytes | ↑MDR1 mRNA | ↓Digoxin |