Table 1

Two highest ASAT, ALAT, and bile acid values, and comparison of clinical features of ICP between familial and sporadic cases

Normal rangeFamilial (n=11)Sporadic (n=58)
Values are mean (SEM) or number (%).
**Statistically significant.
ICP, intrahepatic cholestasis of pregnancy; ASAT, serum aspartate aminotransferase; ALAT, serum alanine aminotransferase.
ASAT(U/l)15–35265.0 (66.0)106.0 (9.0)**
ALAT (U/l)10–40348.7 (85.5)190.5 (22.3)**
Bile acid (μmol/l)<629.4 (4.8)32.0 (4.4)
No of multiple pregnancies149/5304 (2.8%)3/11 (27%)22/58 (38%)
Occurence of ICP in previous pregnancies11/12 (92%)18/45 (40%)**