Multipoint linkage analysis in two Finnish ICP pedigrees
| BSEP | MDR3 | FIC1 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Distance (cM) | D2S2190 (0.0) | 2.40 | D2S111 (4.80) | D7S644 (0.0) | 1.45 | D7S2410 (2.9) | D18S977 (0.0) | 0.75 | D18S849 (1.5) |
| ICP, intrahepatic cholestasis of pregnancy; BSEP, bile salt export pump gene; FIC1, familial intrahepatic cholestasis 1 gene; MDR3, multiple drug resistance 3 gene; LOD score, logarithm of odds score. | |||||||||
| LOD scores were calculated using the Genehunter 2.0 version. | |||||||||
| LOD score family 1 | −0.26 | −0.23 | −0.24 | −1.09 | 0.43 | 0.73 | −1.25 | −1.24 | −1.24 |
| LOD score family 2 | 1.12 | 1.06 | 1.00 | −1.38 | −1.38 | −1.40 | −1.86 | −1.86 | −1.86 |
| Total LOD score | 0.86 | 0.83 | 0.76 | −2.47 | −0.95 | −0.67 | −3.11 | −3.10 | −3.10 |