Comparison of control versus carbon tetrachloride (CCl4) treated animals at baseline and at eight weeks, detailing liver inflammation, parameters of bone metabolism, and bone densitometry
| Baseline | Week 8 | ||||
|---|---|---|---|---|---|
| Controls | CCl4 exposed animals | Controls | CCl4 exposed animals | p Value | |
| AST, aspartate aminotransferase; ALT, alanine aminotransferase; S-Ca2+, serum calcium; 25-OH vit D, 25-hydroxy vitamin D; u-DPD, urinary deoxypyridinoline; BMD, bone mineral density. | |||||
| There were no significant differences between control and CCl4 treated animals at baseline. | |||||
| Weight (g) | 300.3 (215.3–392.5) | 292.8 (182.2–432.8) | 377.7 (277.1–495.5) | 346.4 (219.5–457.5) | NS |
| AST (Iu/l) | 60.22 (5.12) | 62.93 (4.35) | 59.22 (4.80) | 88.75 (6.74) | 0.02 |
| ALT (Iu/l) | 53.67 (2.83) | 55.75 (4.83) | 58.67 (6.10) | 101.1 (24.01) | <0.01 |
| S-Ca2+ (mmol/l) | 2.63 (0.05) | 2.62 (0.13) | 2.58 (0.08) | 2.65 (0.12) | NS |
| u-DPD (nM/mM creatinine) | 127.1 (18.58) | 132.1 (13.48) | 48.91 (13.37) | 54.99 (11.24) | NS |
| Osteocalcin (pg/ml) | 128.0 (11.86) | 127.8 (19.31) | 60.53 (3.30) | 71.78 (11.16) | NS |
| 25-OH vit D (ng/ml) | 25.70 (2.69) | 26.26 (1.81) | 29.33 (2.89) | 20.52 (1.72) | <0.01 |
| High resolution BMD (g/cm2) | |||||
| Proximal femur | 0.3065 (0.014) | 0.3044 (0.031) | 0.3793 (0.044) | 0.3786 (0.018) | NS |
| Proximal tibia | 0.1726 (0.01) | 0.1721 (0.016) | 0.1982 (0.021) | 0.2005 (0.013) | NS |
| Whole body | 0.2674 (0.025) | 0.2654 (0.037) | 0.3311 (0.019) | 0.3430 (0.021) | NS |