Non-parametric (median) univariate and multivariate regression analyses of demographic and virological factors associated with FPR in both HCV monoinfected and HIV-HCV coinfected patients combined
| Factor | Univariate, coefficient (95% CI) | p Value | Multivariable, coefficient (95% CI) | p Value |
|---|---|---|---|---|
| HIV, human immunodeficiency virus; HCV, hepatitis C virus; IDU, injecting drug use; ALT, alanine aminotransferase; FPR, fibrosis progression rate. | ||||
| Duration of HCV infection was excluded from this analysis as it was used to derive FPR and is therefore highly correlated with fibrosis progression rate. | ||||
| Age at HCV infection (y) | 0.0038 (0.002–0.0054) | <0.0001 | 0.0044 (0.0029–0.0059) | <0.0001 |
| Sex (male v female) | 0.0095 (0.0043–0.023) | 0.575 | — | — |
| Source of HCV (IDU v transfusion) | 0.020 (0.0236–0.0646) | 0.360 | — | — |
| HIV positive | 0.0489 (0.006–0.091) | 0.005 | 0.0344 (0.0056–0.0633) | 0.019 |
| Alcohol consumption | 0.0008 (−0.0008–0.001) | 0.616 | — | — |
| ALT level at liver biopsy | 0.0002 (0.00004–0.0004) | 0.014 | 0.0001 (0.00003–0.00035) | 0.039 |
| HCV genotype (1 v others) | 0.0000 (−0.0309–0.0309) | 1 | — | — |
| Inflammatory grade | 0.023 (0.013–0.033) | <0.0001 | 0.0224 (0.0149–0.0300) | <0.0001 |