Dose dependent risks for paracetamol and selected non-steroidal anti-inflammatory drugs for upper gastrointestinal bleeding
| Variable | Daily dose (mg) | OR (95% CI) |
|---|---|---|
| OR (95% CI), odds ratio (95% confidence interval). | ||
| Data are derived from Lewis and colleagues.69 They are based on reported doses used in the week before presentation, and are adjusted for use of aspirin, ketoprofen, anticoagulants, smoking, and past history of upper gastrointestinal problems. | ||
| Paracetamol | <2000 | 1.2 (1.0, 1.4) |
| 2000–3999 | 1.2 (0.8, 1.7) | |
| ⩾4000 | 1.0 (0.5, 1,9) | |
| Ibuprofen | <1200 | 1.1 (0.6, 2.0) |
| 1200–1799 | 1.8 (0.8, 3.7) | |
| ⩾1800 | 4.6 (0.9, 22.3) | |
| Diclofenac | <75 | 2.2 (0.8, 5.8) |
| 75–149 | 3.2 (1.9, 5.5) | |
| ⩾150 | 12.2 (5.6, 26.7) | |
| Piroxicam | ⩽10 | 9.0 (2.1, 39.2) |
| 11–20 | 12.0 (6.5, 22.1) | |
| ⩾21 | 79.0 (9.9, 931.8) | |