Relative risks of gastrointestinal haemorrhage for newer NSAIDs versus older non-specific NSAIDs
| Meloxicam | Coxibs | |||
|---|---|---|---|---|
| Relative risk (95% CI) | p Value | Relative risk (95% CI) | p Value | |
| NSAIDs, non-steroidal anti-inflammatory drugs. | ||||
| *Adjusted for sex, age, any diagnosis of osteoarthritis, any diagnosis of rheumatoid arthritis, recent diagnosis of sprain or strain, recent diagnosis of back pain, history of NSAID use, history of gastrointestinal haemorrhage, recent gastrointestinal endoscopy, any and recent history of gastrointestinal events (erosions, ulcers or bleeding), any and recent history of dyspepsia (including abdominal pain), any and recent prescriptions for ulcer healing drugs, recent prescriptions for nitrates, calcium channel blockers or antacids, alcohol consumption, and tobacco consumption. | ||||
| †Stratified by quintiles of the propensity score distribution for newer NSAIDs. | ||||
| Unadjusted | 1.11 (0.80, 1.50) | 0.532 | 0.56 (0.21, 1.50) | 0.248 |
| Adjusted* | ||||
| Covariates | 0.84 (0.60, 1.17) | 0.303 | 0.36 (0.14, 0.97) | 0.043 |
| Propensity score† | 0.84 (0.60, 1.18) | 0.307 | 0.40 (0.15, 1.06) | 0.066 |
| Both | 0.84 (0.60, 1.18) | 0.418 | 0.36 (0.13, 0.97) | 0.043 |