Clinical and biological features of 17 patients at the time of transplantation for autoimmune hepatitis
| Values are mean (SD) [range] or number. | |
| *One patient had no detectable autoantibodies but gamma globulin was >25 g/l; data not available in three cases. | |
| OLT, orthotopic liver transplantation; ALT, alanine aminotransferase; ANA, antinuclear antibodies; SMA, smooth muscle antibodies; LKM, liver kidney microsome; LC1, liver cytosol type 1. | |
| Age (y) | 30 (12) [12–49] |
| Sex (F/M) | 17/0 |
| Indication for OLT | |
| Decompensated cirrhosis | n=14 |
| Fulminant/subfulminant hepatitis | n=3 |
| Serum markers at transplantation | |
| Prothrombin time (% of normal) | 38 (19.7) [9–82] |
| Total bilirubin (mM/l) | 143.6 (166.25) [22–50] |
| ALT (IU/l) | 246.0 (239.7) [22–605] |
| Gamma globulin level (g/l) | 23.2 (6.1) [14–33] |
| Autoantibodies | |
| ANA and/or SMA >1:80 | n=9* |
| LKM1 and/or LC1 >1:40 | n=4 |
| HLA | |
| DR3+ (1 homozygous and 2 heterozygous) | 3/17 |
| DR4+ (3 heterozygous) | 3/17 |