Descriptive data for healthy control subjects and patients with cirrhosis stratified according to Child-Pugh class
| Controls | Child A | Child B | Child C | |
|---|---|---|---|---|
| Data are mean (SD). | ||||
| Degree of ascites was graded as 0=none, 1=slight, 2=moderate, and 3=tense. | ||||
| P, plasma; GEC, galactose elimation capacity; CrCl, creatinine clearance (values in parentheses are normal values). | ||||
| *p<0.05, **p<0.01 for Child Pugh class C versus A. | ||||
| †p<0.05, ††p<0.01 for Child Pugh class C versus B+A. | ||||
| ‡p<0.05 for Child Pugh class B versus A. | ||||
| §p< 0.05 for controls versus Child Pugh class C, B, and A, respectively. | ||||
| ¶Class B, n=8; class C, n=8. | ||||
| n | 8 | 6 | 13 | 14 |
| Age (y) (median (range)) | 25 (22–39)§ | 52 (41–64) | 51 (40–81) | 50 (33–67) |
| Sex (M/F) | 8/0§ | 4/2 | 6/7 | 11/3 |
| Varices (+/−) | — | 4/2 | 9/4 | 12/2 |
| Ascites (0/1/2/3) | — | 5/1/0/0 | 5/2/5/1 | 1/1/2/8 |
| GEC (μmol/min)¶ (>2.3) | — | 2.0 (0.6)‡ | 1.3 (0.2) | 1.5 (0.3) |
| P-sodium (mmol/l) (136–146) | — | 140 (6) | 135 (4)† | 128 (8)** |
| P-albumin (μmol/l) (596–769) | — | 449 (126) | 433 (65) | 382 (64) |
| P-bilirubin (μmol/l) (<22) | — | 29 (26) | 29 (25)† | 94 (92)* |
| Prothrombin time (s) (0.8–1.2) | — | 0.72 (0.25) | 0.51 (0.13)†† | 0.37 (0.12)** |
| P-potassium (mmol/l) (3.2–5.0) | — | 3.9 (0.3) | 3.8 (0.3) | 4.1 (0.8) |
| P-creatinine (μmol/l) (55–120) | — | 65 (7) | 104 (66) | 78 (30) |
| CrCl (ml/min/1.73 m2) (>80) | — | 72 (19) | 57 (35) | 62 (34) |