Haplotype definition | Haplotype frequency | Significance CD v controls | ||||||
---|---|---|---|---|---|---|---|---|

IGR2060a_1 | IGR2198a_1 | IGR3096a_1 | CD (n = 330) | UC (n=457) | Controls (n = 870) | p Value | RR (95% CI) | |

p values in bold are significant (p<0.05) after Bonferroni correction factor of 8 (number of haplotypes tested for association). | ||||||||

CD, Crohn’s disease; IBD, inflammatory bowel disease; RR, relative risk; UC, ulcerative colitis. | ||||||||

H1 | G | C | T | 39.8 | 48.7 | 48.8 |
<0.0001
| 0.7 (0.6–0.8) |

H2 | C | G | C | 46.8 | 39.6 | 38.9 |
0.0004
| 1.4 (1.2–1.7) |

H3 | G | C | C | 5.5 | 6.2 | 6.8 | — | |

H4 | C | C | C | 3.5 | 2.1 | 2.0 | — | |

H5 | C | G | T | 1.4 | 1.7 | 1.9 | — | |

H6 | G | G | C | 2.3 | 1.3 | 1.0 | — | |

H7 | C | C | T | 0.4 | 0.2 | 0.5 | — | |

H8 | G | G | T | 0.3 | 0.2 | 0.1 | — |