Table 6

IBD5 risk haplotype frequency stratified by Crohn’s disease location

Significance CD subgroup v controls
GroupNo of individualsIBD5 risk haplotype (H2) frequencyp ValueRR (95%CI)
p values in bold are significant (p<0.05) after application of Bonferroni correction factor of 24 (3 phenotypes×8 haplotypes tested for association).
CD, Crohn’s disease; IBD, inflammatory bowel disease; RR, relative risk.
All CD33046.8 0.0004 1.4 (1.2–1.7)
Perianal CD14452.1<0.00011.7 (1.3–2.2)
No perianal CD18642.2
Perianal CD only950.0
Ileal CD25547.3 0.0007 1.4 (1.2–1.7).
Ileal and no perianal CD14842.9
Ileal CD only7438.5
Colonic CD20144.3
Colonic and no perianal CD11239.3
Colonic CD only2348.7
Controls87038.9