Table 7

Genotype and haplotype frequencies of IBD5 risk haplotype in perianal disease

Genotype frequencies
H2/H2 (%)H2/non-H2 (%)Non-H2/non-H2 (%)H2 haplotype frequency (%)
p values in bold are significant (p<0.05) after Bonferroni correction factor of 24 (3 phenotypes×8 haplotypes tested for association).
RR, relative risk.
Perianal (n=144)37 (25.7)76 (52.8)31 (21.5)52.1
No perianal (n=186)39 (21.0)81 (43.5)66 (35.5)42.2
Controls (n=870)128 (14.7)421 (48.4)321 (36.9)38.9
Significance p/RR (95% CI)
    Perianal v no perianal0.02/2.0 (1.1–3.7)0.01/2.0 (1.2–3.4)0.01/1.5 (1.1–2.0)
    Perianal v controls<0.0001/3.0 (1.8–5.0)0.005/1.9 (1.2–2.9)<0.0001/1.7 (1.3–2.2)