IBD5 risk haplotype frequency, stratified by NOD2/CARD15 status
| Genetic stratification | Subjects | H2 haplotype frequency | Significance subgroup v controls | RR (95% CI) | |
|---|---|---|---|---|---|
| p values in bold are significant (p<0.05) after Bonferroni correction factor of 8 (number of haplotypes tested for association). | |||||
| CD, Crohn’s disease; IBD, inflammatory bowel disease; RR, relative risk. | |||||
| CD overall | All | 330 | 46.8 | 0.0004 | 1.4 (1.2–1.7) |
| NOD2/CARD15 pos | 127 | 47.6 | 0.008 | 1.4 (1.1–1.9) | |
| NOD2/CARD15 neg | 203 | 46.3 | 0.006 | 1.4 (1.1–1.7) | |
| Ileal disease | All | 255 | 47.3 | 0.0007 | 1.4(1.2–1.7) |
| NOD2/CARD15 pos | 108 | 46.3 | 0.04 | 1.4 (1.0–1.8) | |
| NOD2/CARD15 neg | 147 | 48.0 | 0.003 | 1.5 (1.1–1.8) | |
| Controls | All | 870 | 38.9 | — | — |