Number and prevalence of adenomas and hyperplastic polyps
| HNPCC | HCRC | TCR | p Value | |
|---|---|---|---|---|
| *Mean (SD). | ||||
| †One way analysis of variance. | ||||
| ‡χ2 test | ||||
| HNPCC, hereditary non-polyposis colorectal cancer; HCRC, hereditary colorectal cancer; TCR, two close relatives with colorectal cancer. | ||||
| No of patients | 108 | 127 | 64 | |
| No of adenomas | 48 | 87 | 51 | |
| Mean age at first colonoscopy | 41.4 | 45.6 | 49.2 | |
| Mean age at last colonoscopy | 44.3 | 49.0 | 51.1 | |
| Subjects with adenomas | 26 | 39 | 25 | |
| No of adenomas (adenomas/individual)* | 0.44 (0.95) | 0.69 (1.63) | 0.80 (1.29) | 0.200† |
| Mean No of adenomas/individual with adenoma | 1.85 | 2.23 | 2.04 | |
| Prevalence: adenoma at first colonoscopy (%) | 16.0 (n=17) | 17.3 (n=22) | 25.0 (n=16) | 0.618‡ |
| Prevalence: ever having an adenoma (%) | 24.1 (n=26) | 31.0 (n=39) | 39.1 (n=25) | 0.115‡ |
| No of hyperplastic polyps | 64 | 139 | 89 | |
| Subjects with hyperplastic polyps | 25 | 44 | 29 | |
| No of hyperplastic polyps (hyperplastic polyps/individual)* | 0.59 (1.37) | 1.09 (2.13) | 1.39 (2.49) | 0.027† |
| Mean No of hyperplastic polyps/individual with hyperplastic polyps | 2.56 | 3.16 | 3.07 | |
| Prevalence: hyperplastic polyp at first colonoscopy (%) | 9.3 (n=10) | 15.7 (n=20) | 31.3 (n=20) | 0.001‡ |
| Prevalence: ever having a hyperplastic polyp (%) | 23.1 (n=25) | 35.0 (n=44) | 45.3 (n=29) | 0.010‡ |