Table 3

Correlation between biochemical iron indices, haematological parameters, and expression of DMT1 (IRE) and Ireg1 in non-HHC subjects and patients with HFE related haemochromatosis

HbHctLog SFTS
Hb, haemoglobin concentration; Hct, haematocrit; TS, transferrin saturation; SF, serum ferritin concentration; HHC, hereditary haemochromatosis DMT1, divalent metal transporter 1; Ireg1, iron regulated gene 1.
Pearson’s correlation coefficient was used to determine whether there was a linear relationship between gene expression of each iron transporter and TS, SF, Hb, or Hct.
Non-HHC subjects (n=23)
    Log DMT1 (IRE)
        r−0.680−0.677−0.569−0.677
        p0.0020.0030.0040.003
    Log Ireg1
        r−0.589−0.574−0.541−0.667
        p0.0020.0030.0070.004
HHC subjects (n=12)
    Log DMT1 (IRE)
        r0.069−0.244−0.7980.049
        p0.8200.4500.0020.881
    Log Ireg1
        r−0.270−0.432−0.620−0.102
        p0.3900.1710.0300.760