Bile flow, biliary secretion of biliary lipids and glutathione, hepatic glutathione content, and maximal bromosulphthalein transport in lean and obese Zucker rats
| 8 week old ZR | 14 week old ZR | |||
|---|---|---|---|---|
| Lean (?/fa) | Obese (fa/fa) | Lean (?/fa) | Obese (fa/fa) | |
| Data represent mean (SEM), n = 4–6 per group. | ||||
| ZR, Zucker rat; SRm, maximal secretory rate; TC, taurocholate; BSP, bromosulphthalein. | ||||
| *p<0.05 compared with respective lean control. | ||||
| Bile flow (µl/min×g liver) | 2.9 (0.2) | 1.6 (0.2)* | 3.1 (0.17) | 1.4 (0.11)* |
| Glutathione (nmol/min×g liver) | 5.5 (0.7) | 1.1 (0.5)* | 8.7 (1.0) | 0.88 (0 38)* |
| Bile salts (nmol/min×g liver) | 92.2 (8.5) | 36.9 (8.8)* | 64.7 (8.0) | 44.7 (8.2) |
| Cholesterol (nmol/min×g liver) | 4.3 (0.8) | 1.0 (0.13)* | 2.3 (0.5) | 0.83 (0.1)* |
| Phospholipids (nmol/min×g liver) | 4.0 (0.6) | 1.4 (0.3)* | 3.8 (0.4) | 1.84 (0.3)* |
| Liver glutathione (nmol/mg liver) | 3.9 (0.5) | 4.3 (0.26) | 4.6 (0.6) | 4.3 (0.45) |
| TC SRm (nm/min×g liver) | 390 (32) | 274 (26.9)* | 278.6 (5.5) | 193.8 (20.4)* |
| BSP SRm (µg/min×g liver) | 29.7 (1.1) | 18.8 (3.2)* | 38.3 (3.5) | 17.2 (0 38)* |