Table 1

 Liver function tests and area of necrosis in rats after 96 hours of CCl4 treatment with or without SSR182289

TreatmentAspartate aminotransferase (IU/l)Alanine aminotransferase (IU/l)Necrosis area (%)
Groups of six rats were treated with two administrations of CCl4 with or without two administrations of SSR182289 and were killed 24 hours after the second CCl4 dose. Values are mean (standard deviation). No difference reached statistical significance.
CCl4255.8 (87.0)117.2 (65.7)10.2 (4.8)
CCl4+SSR182289346.2 (194.0)206.4 (149.8)11.9 (5.0)