Table 1

 Univariate analysis for factors associated with development of hepatocellular carcinoma (HCC)

OverallHCCNo HCCp Value
*Five patients were not evaluated; one patient who developed HCC had a mixed HBV genotype B and C.
†Forty three patients (two had HCC) had a negative polymerase chain reaction (PCR) for BCP mutations and were not evaluated. Twenty patients had genotype B, 21 patients had genotype C, one patient had a mixed genotype B and C, and one patient had a negative PCR for HBV genotyping.
HBeAg, hepatitis B e antigen; ALT, alanine aminotransferase; BCP, basal core promoter.
n42625401
Age (y) (mean (SD))41 (13)52 (10)40 (13)<0.001
Age >40 (n (%))228 (54%)21 (84%)207 (52%)0.006
Male (n (%))278 (65%)21 (84%)257 (64%)0.057
Cirrhosis (n (%))49 (11%)14 (56%)35 (9%)<0.001
HBeAg+ (n (%))157 (37%)10 (40%)147 (37%)0.76
ALT50 (12–1072)64 (41–283)49 (12–1072)0.45
Genotype C (n (%))*242 (57%)18 (75%)224 (56%)0.089
BCP mutations (n (%))†215 (56%)19 (83%)196 (54%)0.017
Follow up (weeks)225 (12–295)121 (14–236)226 (12–295)