Table 2

 Characteristics of the children infected with mutants and amino acid changes in the a determinant of the hepatitis B virus (HBV) in the four study cohorts

aa, amino acids; HBeAg, hepatitis B e antigen.
No of mutant infected children81093
Sex (M/F)4/48/24/52/1
Age (y) (mean (range))6.8 (1.6–10.1)6.5 (1.9–12)6.3 (0.7–12)6.4 (0.2–9.5)
No of HBeAg (+)/No of HBeAg (−)5/38/24/52/1
No of children fully vaccinated1383
Total No of amino acid changes
First loop (aa 124–137)3441
Second loop (aa 139–147)4562
Changes ×10−2/amino acid
    First loop0.200.560.890.55
    Second loop0.431.092.081.71