Multivariate logistic regression models* of the association between antibiotic use and subsequent diagnosis of Crohn’s disease
| OR | 95% CI | |
|---|---|---|
| OR, odds ratio; 95% CI, 95% confidence interval. | ||
| *All models include age and sex as cofactors in addition to those listed. | ||
| †Drugs other than antibiotics represents prescriptions for all other drugs with the exception of antibiotics, and the OR is for moving from one quartile of prescription density to the next. | ||
| ‡For antibiotics the OR is for a comparison of any prescription for that group against none. | ||
| All subjects | ||
| Smoker | 1.55 | 1.22–1.98 |
| Smoking status unknown | 0.86 | 0.64–1.16 |
| Drugs other than antibiotics† | 1.54 | 1.38–1.70 |
| Antibiotics‡ | 1.32 | 1.05–1.65 |
| Subjects with no symptoms or GI drugs 3–5 y pre-diagnosis only | ||
| Smoker | 1.55 | 1.08–2.20 |
| Smoking status unknown | 0.79 | 0.52–1.18 |
| Drugs other than antibiotics | 1.19 | 1.03–1.38 |
| Antibiotics | 1.53 | 1.12–2.07 |