Influence of acute tryptophan depletion (ATD) on affective memory performance in diarrhoea predominant irritable bowel syndrome (d-IBS) patients and control subjects
| d-IBS patients | Controls | ATD v placebo (p value) | ||
|---|---|---|---|---|
| Mean (SEM) percentages of positive, negative, and neutral words recalled immediately (total immediate recall) and recalled after a delay of 30 minutes (delayed recall). | ||||
| *Significant after Bonferroni correction. | ||||
| Total immediate recall | ||||
| Positive words | ATD | 38.4 (4.1) | 42.4 (4.2) | 0.06 |
| Placebo | 45.3 (3.7) | 48.9 (4.4) | ||
| Negative words | ATD | 41.7 (2.2) | 44.4 (3.3) | 0.86 |
| Placebo | 42.0 (4.2) | 43.4 (4.3) | ||
| Neutral words | ATD | 44.8 (4.3) | 50.1 (5.2) | 0.20 |
| Placebo | 46.9 (4.4) | 56.6 (3.8) | ||
| Delayed recall | ||||
| Positive words | ATD | 31.6 (5.6) | 43.5 (7.4) | <0.005* |
| Placebo | 46.1 (5.6) | 52.9 (7.0) | ||
| Negative words | ATD | 41.4 (4.7) | 45.3 (6.1) | 0.40 |
| Placebo | 44.0 (6.8) | 48.2 (7.3) | ||
| Neutral words | ATD | 34.6 (5.9) | 57.5 (8.4) | 0.31 |
| Placebo | 48.6 (7.4) | 57.9 (8.7) | ||