Table 3

 Influence of acute tryptophan depletion (ATD) on affective memory performance in diarrhoea predominant irritable bowel syndrome (d-IBS) patients and control subjects

d-IBS patientsControlsATD v placebo (p value)
Mean (SEM) percentages of positive, negative, and neutral words recalled immediately (total immediate recall) and recalled after a delay of 30 minutes (delayed recall).
*Significant after Bonferroni correction.
Total immediate recall
    Positive wordsATD38.4 (4.1)42.4 (4.2)0.06
Placebo45.3 (3.7)48.9 (4.4)
    Negative wordsATD41.7 (2.2)44.4 (3.3)0.86
Placebo42.0 (4.2)43.4 (4.3)
    Neutral wordsATD44.8 (4.3)50.1 (5.2)0.20
Placebo46.9 (4.4)56.6 (3.8)
Delayed recall
    Positive wordsATD31.6 (5.6)43.5 (7.4)<0.005*
Placebo46.1 (5.6)52.9 (7.0)
    Negative wordsATD41.4 (4.7)45.3 (6.1)0.40
Placebo44.0 (6.8)48.2 (7.3)
    Neutral wordsATD34.6 (5.9)57.5 (8.4)0.31
Placebo48.6 (7.4)57.9 (8.7)