Table 2

Severity of side effects†

Side effectBaselineMonth 1Months 2–3Months 4–6
PlaceboAmantadinePlaceboAmantadinePlaceboAmantadinePlaceboAmantadine
†Severity scored on a scale from 0 (none) to 5 (severe), and results are expressed as mean (SD).
*p<0.05, **p<0.01, ***p<0.001 compared with baseline. There were no significant differences between amantadine and placebo at different time intervals. There were no significant changes in side effects after month 1 in both groups.
Fatigue1.52 (1.48)1.21 (1.41)1.99 (1.42)2.09 (1.35)***2.09 (1.47)*2.14 (1.24)***1.97 (1.59)1.94 (1.28)**
Anorexia0.06 (0.4)0.13 (0.53)0.46 (0.93)**0.67 (1.02)***0.53 (1.06)***0.5 (0.79)**0.41 (0.88)**0.29 (0.7)
Lack of exercise tolerance0.76 (1.38)0.81 (1.34)0.97 (1.38)1.37 (1.55)*1.30 (1.61)*1.47 (1.48)*1.4 (1.67)*1.52 (1.53)**
Nausea0.29 (0.85)0.23 (0.69)0.82 (1.08)**0.81 (1.08)***0.64 (0.98)*0.71 (0.94)**0.46 (0.96)0.57 (0.93)*
Malaise0.75 (1.46)0.44 (1)1.02 (1.25)1.16 (1.37)***1.05 (1.41)1.15 (1.37)**1.05 (1.56)1.01 (1.50)*
Itching0.63 (1.25)0.53 (0.97)0.69 (1.09)0.92 (1.14)*0.95 (1.24)1.12 (1.19)**1.11 (1.46)1.44 (1.46)***
Weight loss0.11 (0.49)0.08 (0.34)0.27 (0.51)*0.39 (0.58)***0.39 (0.71)**0.36 (0.53)***0.36 (0.61)*0.36 (0.61)**
Depression0.33 (0.77)0.31 (0.71)0.71 (1.1)*0.84 (1.17)**0.8 (1.18)**0.91 (1.14)***0.95 (1.26)**0.68 (1.05)*
Insomnia0.96 (1.47)0.54 (1.14)1.05 (1.41)1.42 (1.4)***1.18 (1.27)1.32 (1.31)***1.41 (1.58)1.47 (1.33)***
Dizziness0.09 (0.29)0.21 (0.69)0.58 (0.92)***0.68 (1.05)**0.63 (1.08)***0.78 (1.02)***0.38 (0.79)**0.61 (0.94)*
Blurred vision0.48 (0.99)0.36 (0.89)0.47 (0.94)0.6 (1.02)0.63 (1.2)0.61 (0.96)0.55 (1.12)0.49 (1.03)
Nervousness0.54 (1.02)0.51 (1.06)0.51 (0.89)0.8 (1.15)0.66 (0.95)0.82 (1.23)0.78 (1.21)0.66 (1.23)
Dry mouth0.86 (1.48)0.57 (1.26)1.29 (1.52)1.45 (1.45)***1.5 (1.65)*1.58 (1.63)***1.47 (1.62)*1.63 (1.51)***