Severity of side effects†
Side effect | Baseline | Month 1 | Months 2–3 | Months 4–6 | ||||
---|---|---|---|---|---|---|---|---|
Placebo | Amantadine | Placebo | Amantadine | Placebo | Amantadine | Placebo | Amantadine | |
†Severity scored on a scale from 0 (none) to 5 (severe), and results are expressed as mean (SD). | ||||||||
*p<0.05, **p<0.01, ***p<0.001 compared with baseline. There were no significant differences between amantadine and placebo at different time intervals. There were no significant changes in side effects after month 1 in both groups. | ||||||||
Fatigue | 1.52 (1.48) | 1.21 (1.41) | 1.99 (1.42) | 2.09 (1.35)*** | 2.09 (1.47)* | 2.14 (1.24)*** | 1.97 (1.59) | 1.94 (1.28)** |
Anorexia | 0.06 (0.4) | 0.13 (0.53) | 0.46 (0.93)** | 0.67 (1.02)*** | 0.53 (1.06)*** | 0.5 (0.79)** | 0.41 (0.88)** | 0.29 (0.7) |
Lack of exercise tolerance | 0.76 (1.38) | 0.81 (1.34) | 0.97 (1.38) | 1.37 (1.55)* | 1.30 (1.61)* | 1.47 (1.48)* | 1.4 (1.67)* | 1.52 (1.53)** |
Nausea | 0.29 (0.85) | 0.23 (0.69) | 0.82 (1.08)** | 0.81 (1.08)*** | 0.64 (0.98)* | 0.71 (0.94)** | 0.46 (0.96) | 0.57 (0.93)* |
Malaise | 0.75 (1.46) | 0.44 (1) | 1.02 (1.25) | 1.16 (1.37)*** | 1.05 (1.41) | 1.15 (1.37)** | 1.05 (1.56) | 1.01 (1.50)* |
Itching | 0.63 (1.25) | 0.53 (0.97) | 0.69 (1.09) | 0.92 (1.14)* | 0.95 (1.24) | 1.12 (1.19)** | 1.11 (1.46) | 1.44 (1.46)*** |
Weight loss | 0.11 (0.49) | 0.08 (0.34) | 0.27 (0.51)* | 0.39 (0.58)*** | 0.39 (0.71)** | 0.36 (0.53)*** | 0.36 (0.61)* | 0.36 (0.61)** |
Depression | 0.33 (0.77) | 0.31 (0.71) | 0.71 (1.1)* | 0.84 (1.17)** | 0.8 (1.18)** | 0.91 (1.14)*** | 0.95 (1.26)** | 0.68 (1.05)* |
Insomnia | 0.96 (1.47) | 0.54 (1.14) | 1.05 (1.41) | 1.42 (1.4)*** | 1.18 (1.27) | 1.32 (1.31)*** | 1.41 (1.58) | 1.47 (1.33)*** |
Dizziness | 0.09 (0.29) | 0.21 (0.69) | 0.58 (0.92)*** | 0.68 (1.05)** | 0.63 (1.08)*** | 0.78 (1.02)*** | 0.38 (0.79)** | 0.61 (0.94)* |
Blurred vision | 0.48 (0.99) | 0.36 (0.89) | 0.47 (0.94) | 0.6 (1.02) | 0.63 (1.2) | 0.61 (0.96) | 0.55 (1.12) | 0.49 (1.03) |
Nervousness | 0.54 (1.02) | 0.51 (1.06) | 0.51 (0.89) | 0.8 (1.15) | 0.66 (0.95) | 0.82 (1.23) | 0.78 (1.21) | 0.66 (1.23) |
Dry mouth | 0.86 (1.48) | 0.57 (1.26) | 1.29 (1.52) | 1.45 (1.45)*** | 1.5 (1.65)* | 1.58 (1.63)*** | 1.47 (1.62)* | 1.63 (1.51)*** |