Biliary lipid secretion and cholesterol saturation indices
| Treatment group (No) | BS† | PC† | Chol† | CSI‡ |
|---|---|---|---|---|
| LD, lithogenic diet; BS, bile salt; PC, phosphatidylcholine (biliary phospholipid); Chol, cholesterol; CSI, cholesterol saturation index. | ||||
| †Values are expressed as nmol/min×100 g (body weight). | ||||
| ‡Dimensionless values. | ||||
| *p<0.05 v controls. | ||||
| C57L mice fed Ro displayed higher BS secretion rates than controls whereas the single Tu fed group showed lower levels. Higher Chol secretion rates were observed in Ro 30 and Ro 60 fed animals compared with controls. Statistically significant elevations in biliary phospholipid secretion rates compared with controls were demonstrated in all Ro and Tu drug groups in both C57L and AKR mice. Chol and BS secretion were not changed significantly in AKR mice. CSI of murine hepatic bile in the fed state were calculated using critical tables26 for taurocholate, the principal murine bile salt in the LD. Chol desaturation of bile was evident in the Ro 100 and Tu 60 treatment groups as well as in AKR mice on LD alone. All other groups displayed supersaturated and lithogenic bile, as evidenced by the study. | ||||
| C57L-LD | ||||
| 5 | 657 (62) | 64 (10) | 19 (4) | 106 (14) |
| Ro 30 | ||||
| 6 | 824 (79) | 138 (6)* | 58 (60* | 149 (15) |
| Ro 60 | ||||
| 5 | 766 (156) | 111 (18)* | 43 (7)* | 131 (22) |
| Ro 100 | ||||
| 4 | 692 (29) | 94 (80* | 26 (2) | 80 (5) |
| Tu 60 | ||||
| 5 | 520 (47) | 104 (5)* | 28 (3) | 92 (10) |
| AKR-LD | ||||
| 6 | 381 (153) | 42 (10) | 18 (5) | 79 (8) |
| AKR-simva | ||||
| 3 | 415 (89) | 64 (10)* | 26 (4) | 120 (1) |
| C57-simva | ||||
| 5 | 480 (48) | 67 (9) | 18 (2) | 88 (16) |
| AKR-Ro 100 | ||||
| 5 | 314 (59) | 58 (9)* | 20 (3) | 112 (8) |