Table 2

Studies using animal models with mice deficient of organised gut associated lymphoid tissue (GALT) organs and/or lymphotoxin α/β pathway

Animal modelGALT organ defectOutcome in course of intestinal inflammationReference
ALF, appendix associated lymphoid follicle; DC, dendritic cell; DSS, dextran sodium sulphate; LTα/β, -R, lymphotoxin α/β, -receptor; LTβRIgG, lymphotoxin β receptor-IgG fusion protein; MLN, mesenteric lymph node; PP, Peyer’s patch; TH, T helper; TNBS, trinitrobenzene sulphonic acid; TNF-R, tumour necrosis factor receptor; UC, ulcerative colitis.
*Mice were from a litter of mice which had been treated during gestation with LTβRIgG.
†Mice were treated at adult age.
‡w/o, without; induction of PP/MLN defect by gestational treatment with LTβRIgG/TNFRI-IgG.
Spontaneous colitis in TCRα−/− miceAppendix/ALFAppendectomy protects against disease if performed at a young age 55
Interleukin-2−/− mice, interleukin-2 R α chain−/− miceLymph node enlargementDevelopment of colitis similar to UC. Anti-colon antibodies, T and B cell activation 57, 58
TNBS colitis in wild-type micePP/colonic follicles*Focal ulcers, TH1 response instead of TH1/TH2 response 62
TNBS colitis in γ-IFN−/− miceLTβRIgG treatment†Loss of PP, reduction of DC in the colon, decreased disease severity in TH2-type colitis 62
Oxazolone colitisWild-type miceInflammation of distal colon, mucosal inflammation at early stage (48 h), transmural inflammation at late stage (7 days) 103, 104
CD45RBhi T cell transfer colitisLTβRIgG treatment†Decreased disease severity 61
Tgϵ26 T cell transfer colitisLTβRIgG treatment†Decreased disease severity 61
DSS induced colitisAppendectomyDecreased disease severity 60
DSS induced colitisLTα−/− mice w/o‡ PP/MLNIncreased disease severity. Induction of colonic lymphoid tissue 64
DSS induced colitisWild-type mice w/o‡ PP/MLNIncreased disease severity. Induction of colonic lymphoid tissue 64
DSS induced colitisWild-type mice w/o‡ PP with MLNNo effect on disease severity 64
Citrobacter rodentium induced infectious colitisTNF-R-I (55 kDa) gene deficient mice with small PPIncreased intestinal secretion of infectious agent clearance of bacteria and survival similar to wild-type mice 105