Mucosal mast cells in duodenal and rectal sites in patients with cholera and in healthy controls
| Study day‡ | Lamina propria | Epithelium | Total | ||
|---|---|---|---|---|---|
| Crypt | Villus | Crypt | Villus | ||
| Adult duodenal tissue | |||||
| Day 2 | 9.7 (8.0–14.6) | 5.81 (4.14–8.3) | 2.78 (0.96–3.70)*† | 0.01 (0.01–0.26) | 18.35 (15.3–27.9) |
| Day 7 | 17.7 (14.7–32.3)† | 7.6 (6.7–13.3) | 1.3 (0.53–3.94) | 0.01 (0.01–0.46) | 30.5 (21.1–50.0)*† |
| Day 30 | 23.1 (19.8–31.7)† | 15.9 (10.81–18.92)† | 1.16 (0.45–1.54) | 0.01 (0.01–0.01) | 41.32 (31.53–49.1)*† |
| HC | 7.1 (1.13–26.9) | 5.61 (3.6–16.13) | 0.57 (0.01–2.01) | 0.01 (0.01–0.01) | 13.23 (4.62–49.1) |
| Deeper | Upper | Deeper | Upper | Total | |
|---|---|---|---|---|---|
| ‡Days after onset of disease in patients. | |||||
| HC, healthy controls. | |||||
| Significant difference (*p⩽0.05) between patients and controls; significant difference (†p⩽0.05) between the acute and convalescent stages of the disease. | |||||
| Adult rectal tissue | |||||
| Day 2 | 11.03 (8.63–15.73) | 3.92 (2.62–5.56) | 0.68 (0.01–2) | 0.51 (0.01–1.45) | 17.84 (12.6–26.9) |
| Day 7 | 15.30 (12.03–28.7)† | 10.1 (3.1–13.1) | 1.2 (0.40–1.62) | 0.40 (0.01–1.80) | 36.1 (15.3–45.0)† |
| Day 30 | 15.60 (10.11–18.7) | 6.82 (4.2–10.30) | 0.83 (0.12–1.14) | 0.38 (0.01–1.53) | 23.25 (16.2–28.92) |
| HC | 12.54 (6.33–14.82) | 3.11 (3.05–5.56) | 0.49 (0.46–1.28) | 0.43 (0.01–3.29) | 16.39 (10.29–22.91) |
| Paediatric rectal tissue | |||||
| Day 2 | 14.61 (9.75–17.58) | 4.42 (2.68–10.07) | 1.16 (0.38–2.63) | 0.72 (0.01–1.36) | 22.16 (13.78–31.37) |
| Day 7 | 15.79 (12.59–23.61) | 8.72 (4.59–11.82) | 2.47 (0.90–4.89) | 0.48 (0.01–2.39) | 35.42 (19.52–47.35)*† |
| Day 30 | 20.13 (12.26–31.85) | 7.34 (5.19–10.16) | 2.0 (1.37–3.61) | 0.55 (0.01–1.55) | 31.0 (20.21–42.41)* |
| HC | 10.75 (8.92–14.02) | 5.86 (1.69–7.12) | 1.06 (0.74–1.74) | 0.63 (0.39–1.29) | 19.85 (11.57–24.04) |