Ultrastructural studies of mast cells in the duodenal mucosa of study subjects
| Type of change | Healthy controls (n = 23)† | O1 patients (day 2)‡ (n = 50) | O1 patients (day 7) (n = 35) | O1 patients (day 30) (n = 34) | O139 patients (day 2) (n = 17) | O139 patients (day 7) (n = 9) | O139 patients (day 30) (n = 16) |
|---|---|---|---|---|---|---|---|
| †n = number of mast cells studied ultrastructurally. | |||||||
| ‡Days after onset of disease in patients. | |||||||
| §Numbers indicate percentage of cells with the particular type of activation that were studied. | |||||||
| *p<0.05, χ2 or Fisher’s exact test was used to determine statistically significant differences between patients at the different stages of infection and healthy controls. | |||||||
| PMD, piecemeal degranulation; AND, anaphylactic degranulation. | |||||||
| Normal | 35§ | 12* | 6* | 6* | 0* | 0* | 0* |
| PMD (1+) | 35 | 6* | 17 | 32 | 12 | 44 | 18 |
| PMD (2+ to 3+) | 0 | 61* | 60* | 53* | 71* | 33* | 25* |
| AND | 26 | 20 | 18 | 15 | 12 | 22 | 62* |
| Lipid body activation | 35 | 56 | 60 | 50 | 82* | 77* | 62 |