Ultrastructural studies of eosinophils in the duodenal mucosa of study subjects
| Type of change | Healthy controls (n = 25)† | O1 patients (day2) (n = 40) | O1 patients (day 7) (n = 34) | O1 patients (day 30) (n = 27) | O139 patients (day 2) (n = 10) | O139 patients (day 7) (n = 12) | O139 patients (day 30) (n = 13) |
|---|---|---|---|---|---|---|---|
| †n = number of eosinophils studied ultrastructurally. | |||||||
| ‡Percentages of cells with the particular type of activation that were studied. | |||||||
| *p<0.05, χ2 or Fisher’s exact test was used to determine statistically significant differences between patients at the different stages of infection and healthy controls. | |||||||
| PMD, piecemeal degranulation. | |||||||
| Normal | 60‡ | 0* | 0* | 0* | 10* | 8* | 8* |
| PMD (1+) | 20 | 19 | 21 | 7 | 10 | 33 | 31 |
| PMD (2+ to 3+) | 4 | 78* | 77* | 88* | 60* | 16 | 16 |
| PMD (core) | 0 | 7 | 15* | 19* | 0 | 16 | 8 |
| PMD (matrix) | 12 | 43* | 44* | 26 | 50* | 25 | 8 |
| PMD (core and matrix) | 4 | 48* | 35* | 48* | 20 | 8 | 0 |
| Degranulation and activation | 8 | 63* | 79* | 59* | 60* | 42* | 23 |
| Necrosis | 8 | 10 | 15 | 33* | 20 | 50* | 62* |