Table 1

Patient characteristics, CDH-1 mutation, and endoscopy details

Patient APatient BPatient CPatient DPatient EPatient F
IM, intestinal metaplasia.
Age (y)/sex40/M28/M15/F34/F43/F33/F
CDH-1 mutation1008-G→T truncatingSame kindred as ASame kindred as ASame kindred as A1792-C→T truncating2287-G→T truncating
Endoscopic findingsChromoendoscopy, 1 pale area greater curve at body-antrum junctionChromoendoscopy, 2 pale areas greater curve at body-antrum junctionChromoendoscopy, 5 pale areas greater curve, body-antrum junctionChromoendoscopy, 1 pale area distal body on posterior wallStandard endoscopy, mild reflux oeosophagitisStandard endoscopy, 4 mm antral ulcer greater curve
Endoscopic biopsySignet ring cell carcinomaSignet ring cell carcinomaSignet ring cell carcinomaSignet ring cell carcinomaNormalSignet ring cell carcinoma
H pylori statusNot infectedNot infectedNot infected5 y preop: H pylori gastritis14 months preop: H pylori gastritisNot infected
Pathology in gastrectomy specimens
    Macroscopic appearanceNormalNormalNormalNormalNormalNormal
    No of blocksExtensive sampling 72 blocksComplete stomach 247 blocksComplete stomach 183 blocksComplete stomach 207 blocksComplete stomach 271 blocksComplete stomach 139 blocks
    No of foci (size of foci (mm))45 (0.2–9)214 (0.2–9)318 (0.1–10)111 (0.1–4)4 (1–3)32 (0.1–4.5)
    Non-neoplastic findingsNo IMNo IMNo IM, chronic gastritis in bodyNo IMIM and focal atrophy in antrumFocal IM in antrum
    H pyloriNo organismsNo organismsNo organismsNo organismsNo organismsNo organisms
    Metastasis/lymph nodes0/70/260/230/150/140/6