Distribution of various clinical parameters among patients with chronic pancreatitis based on N34S SPINK1 mutation status
| HP (n = 37) | ICP (n = 120) | ACP (n = 41) | ||||
|---|---|---|---|---|---|---|
| Mutated SPINK1 | Mutation negative | Mutated SPINK1 | Mutation negative | Mutated SPINK1 | Mutation negative | |
| n, number of patients; HP, hereditary pancreatitis; ICP, idiopathic chronic pancreatitis; ACP, alcohol related pancreatitis. | ||||||
| *p = 0.045 for HP; p = 0.177 for ICP; p = 0.091 for ACP. | ||||||
| †p = 0.978 for HP; p = 0.505 for ICP; p = 0.741 for ACP. | ||||||
| Percentages refer to the proportion of patients within each group. | ||||||
| n | 27 | 10 | 38 | 82 | 10 | 31 |
| Age at presentation (y) (median, range 95% CI) | 35.0 (31.5–36.1) | 39.5 (36.5–44.3) | 24.0 (22.2–28.8) | 28.5 (27.8–32.9) | 31.0 (28.8–38.2) | 41.0 (38.3–43.3) |
| Age at onset (y)* (median, range 95% CI) | 23.5 (21.2–29.2) | 24.5 (23.2–31.8) | 19.5 (17.8–24.2) | 25.0 (24.6–29.7) | 28.0 (24.2–34.5) | 38.0 (34.8–40.0) |
| Clinical parameters | ||||||
| Nature of pain | ||||||
| Intermittent | 18 (74.1%) | 3 (30%) | 18 (47.4%) | 19 (23.2%) | 4 (40%) | 5 (16.1%) |
| Constant | 6 (22.2%) | 6 (60%) | 14 (36.8%) | 54 (65.8%) | 4 (40%) | 24 (77.4%) |
| Diabetes mellitus† | 11 (40.7%) | 4 (40%) | 4 (10.5%) | 15 (18.3%) | 3 (30%) | 5 (16.1%) |
| Smoking | 4 (14.8%) | 3 (30%) | 6 (15.8%) | 22 (26.8%) | 2 (20%) | 8 (25.8%) |
| Pseudocyst | 4 (14.8%) | 2 (20%) | 6 (15.8%) | 20 (24.4%) | 2 (20%) | 8 (25.8%) |