Table 4

 NOD2 genotypes in the study populations

CD cohort 1 (n = 334)†††CD cohort 2 (n = 114)††UC (n = 163)Controls (n = 140)
CD, Crohn’s disease; UC, ulcerative colitis.
All p values are compared with controls: †††p<0.001, ††p = 0.004.
p values for NOD2 allele frequencies compared with controls: for Arg702Trp, *0.019; **0.28; ***NS; for Gly908Arg, *0.019; **0.15; ***NS; forLeu1007fsinsC, *0.0004; **0.0019; ***NS.
Genotype
    Wild-type184 (55.1%)67 (58.8%)135 (82.9%)109 (77.8%)
    Heterozygous122 (36.5%)41 (35.9%)25 (15.3%)28 (20.0%)
    Homozygous mutant or  compound heterozygous28 (8.4%)6 (5.3%)3 (1.8%)3 (2.2%)
Allele frequencies (minor allele)
    Arg702Trp12.3%*11.4%**5.5%***6.8%
    Gly908Arg5.7%*3.9%**2.4%***2.1%
    Leu1007fsinsC8.9%*8.0%**1.5%***2.5%