Table 1

Trends in incidence and manifestations of Crohn’s disease (Northern France 1988–99)

1988–90 (n = 793)1991–93 (n = 1030)1994–996 (n = 1054)1997–99 (n = 1136)
*Standardised for European Population (95% confidence interval (CI))
†Values are median (range 25th–75th percentiles).
‡Both small and large bowel
Standardised incidence rate (/105) (95% CI)*
    All (n = 4013)5.2 (4.8–5.5)5.8 (5.4–6.1)5.9 (5.5–6.2)6.4 (6.0–6.8)
    Men (n = 1789)4.4 (4.0–4.9)5.6 (5.1–6.1)5.3 (4.8–5.8)5.7 (5.2–6.2)
    Women (n = 2224)5.9 (5.3–6.4)6.0 (5.4–6.5)6.4 (5.9–6.9)7.1 (6.6–7.7)
    Nord (n = 1782)4.7 (4.2–5.1)5.5 (5.0–6.0)5.8 (5.2–6.3)6.4 (5.8–6.9)
    Pas-de-Calais (n = 1149)6.2 (5.5–7.0)6.6 (5.8–7.3)6.0 (5.3–6.8)7.5 (6.7–8.3)
    Somme (n = 524)6.3 (5.1–7.5)8.2 (6.8–9.6)8.3 (6.9–9.7)8.0 (6.6–9.3)
    Seine-Maritime (n = 558)3.1 (2.1–4.1)4.3 (3.7–5.0)4.9 (4.2–5.6)4.5 (3.8–5.1)
Symptoms (%) (n = 4013)
    Diarrhoea67.071.068.269.8
    Blood in stools36.432.633.334.6
    Abdominal pain78.380.884.279.9
    Fever33.130.930.726.1
    Extradigestive symptoms15.614.610.913.4
    Anoperineal16.516.113.515.1
Age at diagnosis (y)†26 (20–38)27 (21–38)27 (21–39)27 (20–38)
Interval before diagnosis (months)†4 (1–12)3 (1–12)3 (1–9)3 (1–9)
Complete digestive investigation‡ (%) (n = 4013)79.876.073.777.9
Location (%) (n = 3056)
    Small bowel21.619.020.621.2
    Large bowel26.420.915.714.0
    Ileocolonic51.960.163.864.8