NOx, TNF-α, IFN-γ, and IL-12 levels in ascitic fluid in patients in groups I and II
| NOx (nmol/106 cells) | iNOS (U/106 cells) | TNF-α (pg/106 cells) | IFN-γ (nmol/106 cells) | IL-2 (pg/106 cells) | IL-12 (pg/106 cells) | |
|---|---|---|---|---|---|---|
| Data are mean (SD). | ||||||
| NOx, sum of nitric oxide metabolites, nitrite and nitrate; TNF-α, tumour necrosis factor α; IFN-γ, interferon γ; IL-2 and IL-12, interleukin 2 and 12, respectively; iNOS, inducible form of nitric oxide synthase. | ||||||
| Basal, ascitic fluid (AF) samples obtained at admission; 24 h, supernatant of culture after 24 hours without stimulation; 24 h+LPS, supernatant of culture after 24 hours with addition of lipopolysaccharide (LPS) to the culture medium. | ||||||
| *p<0.05 versus the corresponding value in group I; †p<0.05 versus the corresponding value after 24 hours without stimulation. | ||||||
| Group I | ||||||
| Basal | 21.2 (13.0) | 4.5 (3.1) | 15.6 (4.4) | 26.9 (5.8) | 22.1 (6.0) | 9.1 (1.7) |
| 24 h | 57.5 (22.4) | 7.5 (3.9) | 21.9 (9.3) | 31.0 (6.1) | 29.3 (7.1) | 12.5 (6.0) |
| 24 h+LPS | 85.6 (26.9)† | 24.2 (10.3)† | 57.6 (5.6)† | 52.7 (5.7)† | 61.0 (10.3)† | 76.0 (9.7)† |
| Group II | ||||||
| Basal | 35.6 (20.8) | 13.2 (4.5)* | 35.3 (17.7)* | 40.2 (8.0)* | 62.1 (10.3)* | 71.7 (7.8)* |
| 24 h | 93.2 (35.6)* | 17.1 (5.1)* | 46.0 (9.0)* | 46.1 (8.8) | 68.0 (10.3)* | 80.3 (6.9)* |
| 24 h+LPS | 122.3 (44.5)* | 28.6 (7.7)† | 63.2 (10.2)† | 55.4 (8.2)† | 74.1 (9.0)† | 90.6 (9.5)† |