Table 1

Features at diagnosis of asymptomatic and asymptomatic patients

Initially asymptomatic patients (n =  469)Initially symptomatic patients (n = 301)p Value
AMA, antimitochondrial antibodies; ANF, antinuclear factor antibodies; SMA, smooth muscle antibodies; LFT, liver function tests.
*Autoantibody data available for 767 patients.
†LFT results expressed as ratio to upper limit of normal (except bilirubin).
‡Histology at diagnosis available for 332 patients.
Median age (y)63.161.80.10
No female (%)412 (87%)282 (93%)0.008
Autoantibody status*
    AMA positive (>1 in 40)422 (90.3%)268 (89.3)0.73
    ANF positive68 (14.6%)37 (12.3%)0.44
    SMA positive24 (5.1%)17 (5.6%)0.88
    AMA titre >1 in 60136 (29.1%)102 (34.0%)0.06
LFTs at diagnosis†
    Alkaline phosphatase2.09 (1.30–4.20)2.47 (1.42–5.94)0.005
    Alanine transaminase1.12 (0.71–2.00)1.48 (0.88–2.67)0.001
    Bilirubin (μmol/l)8.9 (7.0–15.0)10.9 (7.0–23.9)<0.001
    Prothrombin ratio1.0 (0.91–1.00)1.0 (0.92–1.0)0.91
Histology at diagnosis‡
    Precirrhotic146 (84%)107 (68%)
    Cirrhotic28 (16%)51 (32%)<0.001