Biochemical, histological, and virological features divided with respect to tumour necrosis factor (TNF) polymorphisms
| TNF | TNF | |||||
|---|---|---|---|---|---|---|
| −238 A/G | −238 G/G | p Value | −308 A/G | −308G/G | p Value | |
| HCV, hepatitis C virus; AST, aspartate aminotransferase; ALT, alanine aminotransferase; AP, alkaline phosphatase; GGT, gamma glutamyl transpeptidase. | ||||||
| Infection duration (y) | 19 (12) | 16 (9) | NS | 17 (10) | 15 (9) | NS |
| Alcohol | ||||||
| Yes | 8 | 57 | 21 | 44 | NS | |
| No | 23 | 154 | NS | 44 | 133 | |
| Body mass index (kg/m2) | 27.1 (5.4) | 26.4 (5.4) | NS | 25.4 (5.7) | 27.6 (5.8) | NS |
| AST (U/l) | 69 (63) | 70 (51) | 0.24 | 74 (49) | 68 (54) | NS |
| ALT (U/l) | 123 (130) | 122 (96) | NS | 138 (93) | 119 (103) | NS |
| AP (U/l) | 188 (68) | 181 (78) | NS | 183 (68) | 181 (80) | NS |
| GGT (U/l) | 60 (47) | 47 (42) | NS | 47 (44) | 49 (42) | NS |
| Ferritin (ng/ml) | 214 (144) | 140 (139) | NS | 150 (167) | 149 (133) | NS |
| HCV Viral load (Th IU/ml) | 1026 (1048) | 1170 (1425) | NS | 1157 (1432) | 1115 (1332) | NS |
| Portal inflammation | 2.7 (0.9) | 2.4 (1.1) | NS | 2.5 (1.03) | 2.5 (1.0) | NS |
| Lobular inflammation | 1.93 (0.9) | 1.8 (0.9) | NS | 1.85 (1.02) | 1.8 (0.9) | NS |
| Perl’s stain (+) | 6 | 60 | NS | 18 | 48 | NS |
| Perl’s stain (−) | 21 | 137 | 42 | 116 | ||
| Steatosis (yes) | 15 | 80 | NS | 24 | 71 | NS |
| Steatosis (no) | 12 | 117 | 36 | 93 | ||