Changes associated with carbon tetrachloride (CCl4) induced cirrhosis
| Control | Cirrhotic | p Value | |
|---|---|---|---|
| Following treatment with CCl4 for eight weeks, rats were anaesthetised and cannulated as described in materials and methods. After determination of portal and arterial pressure, the liver and spleen were removed and weighed. Hepatic PAF concentration was determined as described in the methods section. | |||
| Values are means (SD) from 6–7 rats. | |||
| MAP, mean arterial pressure; PAF, platelet activating factor. | |||
| Liver/body weight ratio (%) | 4.8 (0.25) | 4.9 (0.44) | NS |
| Weight of spleen (g) | 0.73 (0.06) | 1.36 (0.15) | 0.001 |
| Portal pressure (mm Hg) | 5.3 (0.6) | 12.2 (0.7) | 0.001 |
| MAP (mm Hg) | 114 (9) | 82 (10) | 0.01 |
| PAF (ng/g) | 2.74 (0.49) | 3.95 (0.43) | 0.01 |