Table 3

 Annotated genes differentially expressed in Marsh III (MIII) versus Marsh 0 (M0), grouped according to their function*

Gene symbolGene nameLocusLink IDChromosome locationRatio MIII/M0†
*All of the genes can be found at http://humgen.med.uu.nl/publications/CD/Microarrays/Diosdado_1.html.
†Ratio of the expression level for each individual gene when comparing MIII coeliac disease biopsies with M0 biopsies. Genes with values <1 are downregulated; genes with values >1 are upregulated.
‡Genes located in more than one functional group.
Immune response related
    C8BComplement component 8, beta polypeptide7321p32.10.67
    HF1H factor 1 (complement)30751q31.30.80
    MSR1Macrophage scavenger receptor 144818p221.25
    TXNThioredoxin72959q31.31.26
    IL2RBInterleukin 2 receptor β356022q13.11.36
Chemokines, cytokines, and growth factors
    BTN2A1‡Butyrophilin, BTF1 precursor111206p22.21.18
Inflammatory mediators
    PRG1Proteoglycan 1, secretory granule555210q22.11.21
Cancer related genes
    DKFZP586A011Cervical cancer 1 proto oncogene2587512q13.130.72
    C20orf64Chromosome 20 open reading frame 6411285820q13.121.30
Structural related genes
    TM4SF4Transmembrane 4 superfamily member 471043q25.10.50
    IGFBP7Insulin-like growth factor binding protein 734904q120.73
    EPB42Erythrocyte membrane protein band 4.2203815q15.20.79
    BTN2A1‡Butyrophilin, BTF1 precursor111206p22.21.18
    SLC9A3R1Solute carrier family 9, isoform 3 regulatory factor 1936817q25.11.20
    RBP4Retinol binding protein 4, interstitial595010q23.331.24
    KIAA1029Synaptopodin113465q33.11.43
Signal transduction
    PPP3CBCalcineurin A beta553210q22.20.76
    RAP1GDS1RAP1, GTP-GDP dissociation stimulator 159104q231.22
    RAB1BRAB1B, member RAS oncogene family8187611q13.31.23
    ANXA6Annexin A63095q33.11.24
    LCP1Lymphocyte cytosolic protein 1393613q14.131.30
    TYK2Tyrosine kinase 2729719p13.21.30
    JFC1NADPH oxidase related, C2 domain containing protein849581p35.21.34
Metabolic pathways and ion transport mediators
    ALDOBAldolase B, fructose bisphosphate2299q31.10.51
    PDE7BPhosphodiesterase 7B271156q23.30.64
    FLJ12899Pantothenate kinase 3796465q340.71
    HSD3B1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid-132831p120.82
    ABCA7ATP binding cassette, subfamily A, member 71034719p13.31.18
    APOA2Apolipoprotein A-II3361q23.31.21
    SRISorcin67177q21.121.23
    GYG2Glycogenin 28908Xp22.331.27
    SMUG1Single strand selective monofunctional uracil DNA glycosylase2358312q13.131.29
    MRPS22Mitochondrial ribosomal protein S22569453q231.29
    KCNQ3Potassium voltage gated channel, KQT-like subfamily, member 337868q24.221.30
    ATP1A2ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide4771q23.21.30
    DIA1Diaphorase (NADH)172722q13.21.30
Cell cycle regulators and transcription factors
    HBP1HMG-box containing protein 1269597q22.30.83
    KHDRBS1Sam 68106571p35.11.11
    NAP1L4Nucleosome assembly protein 1-like 4467611p15.41.27
    C20orf64Chromosome 20 open reading frame 6411285820q13.121.30
    C21orf66Chromosome 21 open reading frame 669410421q22.111.38
Cell-cell signalling
    ECM2Extracellular matrix protein 218429q22.311.24
    RIMS1Regulating synaptic membrane exocytosis 1229996q131.29
    GRM3Glutamate receptor, metabotropic 329137q21.121.37
Protein synthesis
    EIF4EBP3Eukaryotic translation initiation factor 4E binding protein 386375q31.30.72
    EIF2B3Eukaryotic translation initiation factor 2B, subunit 388911p34.11.27