Table 1

 Diagnostic criteria used to type 274 focal liver lesions subjected to fine needle biopsy

DiagnosisPathological criteria (reference)Other requirements
*Contrast enhanced computed tomography or contrast enhanced magnetic resonance (see methods for criteria and details).
HCC, hepatocellular carcinoma; US, ultrasound.
HCC (histology)Multiple liver cell plates in trabecular, solid, or acinar patterns surrounded by a network of sinusoidal vessels with stroma; scanty reticular architecture; invasion of veins in portal tract15None
HCC (cytology)Nuclear hyperchromasia; increased nuclear-cytoplasmic ratio; trabecular pattern; nucleolar prominence; atypical naked nuclei; bizarre mitotic figures16None
Dysplastic nodules (mild dysplasia)Plates ⩽2 cells thick; intact reticular architecture; no infiltrative edge; large cell dysplasia in some cases17Confirmation by second imaging study*+clinical and US follow up
Dysplastic nodules (severe dysplasia)Plates ⩽3 cells thick; foci of decreased reticulum staining; irregular edges; small cell dysplasia and/or isolated glandular structures in some cases17Confirmation by second imaging study*+clinical and US follow up
Regenerative nodulesHyperplastic hepatocytes relative or similar to the surrounding liver, generally uniform in structure, with elements of portal tracts regularly distributed inside; absence of cellular and nuclear atypia18Confirmation by second imaging study*+clinical and US follow-up
Non-Hodgkin’s lymphomaAtypical lymphoid cells, mono- or polymorphic, whose monoclonal origin was confirmed by immunocytochemical techniques19None
HaemangiomaAbundant endothelial cells surrounded by stroma in the absence of other types of cellsConfirmation by second imaging study*+clinical and US follow up