Table 4

Helicobacter pylori eradication with triple therapy (proton pump inhibitor-amoxicillin-clarithromycin) according to clarithromycin susceptibility or resistance

ReferenceType of studyTreatmentEradication rate
OverallClarithromycin susceptibleClarithromycin resistant
*Second line treatment.
†Children.
O, omeprazole; L, lanzoprazole; P, pantoprazole; C, clarithromycin; M, metronidazole; R, ranitidine; A, amoxicillin; PPI, proton pump inhibitor.
Bago10RandomisedOAC 1 week84% (37/44)89.7% (35/39)40% (2/5)
Bochenek94RandomisedPAC 1 week66.5% (137/206)77.3% (130/18229.1% (7/24)
Ducons95SuccessiveLAC 1 week79% (79/100)85.5% (77/90)20% (2/10)
Hoshiya96Not randomisedOAC, LAC 1 week77.5% (83/107)83.1% (79/95)33.3% (4/12)
Kalach97SuccessiveOAC, LAC 1 week81.9% (50/61)100% (50/50)0% (0/11)
Katelaris98RandomisedPAC 1 week80.4% (37/46)86% (36/42)25% (1/4)
Kawabata99RandomisedLAC, RAC 1 week78% (135/173)85.5% (130/152)23.8% (5/21)
Kihira100RandomisedRAC92.6% (79/85)96.3% (79/82)0% (0/3)
Laine25RandomisedOAC85.8% (91/106)94.6% (88/93)23% (3/13)
Lamouliatte101RandomisedPAC 1 week81.1% (82/101)86% (82/95)0% (0/6)
Lamouliatte102*RandomisedOAC 1 or 2 weeks48.3% (57/118)80% (48/60)15.5% (9/58)
Lehman103RandomisedLAC 2 weeks72% (23/32)87% (23/29)0% (0/3)
Lind104RandomisedOAC 1 week95.7% (113/118)97% (111/116)100% (2/2)
McMahon105Not randomisedLAC 2 weeks71.6% (38/53)87.5% (35/40)23% (3/13)
Miki106RandomisedOAC, R AC 1 week87% (120/138)97.5% (119/122)6.3% (1/16)
Murakami107RandomisedRAC, LAC 1 week85.3% (227/266)94% (226/241)4% (1/25)
Peitz108*RandomisedOAC 1 week48.5% (17/35)83% (10/12)30% (7/23)
Pilotto109RandomisedPAC 1 week85% (34/40)87% (33/38)50% (1/2)
Poon110RandomisedLAC 1 week84% (37/44)95% 37/39)0% (0/5)
Tankovic111SuccessiveOAC 1 week67.6% (69/102)79% (67/85)12% (2/17)
Total78.2% (1545/1975)87.8% (1495/1702)18.3% (50/273)