Clinical behaviour in primary sclerosing cholangitis patients by prior appendicectomy
| Clinical parameter | App+ (n (%)) | App− (n (%)) | p Value |
|---|---|---|---|
| App+, prior appendicectomy; App−, no appendicectomy prior to diagnosis. | |||
| PSC, primary sclerosing cholangitis; IBD, inflammatory bowel disease; CholangioCa, cholangiocarcinoma. | |||
| *Seven colectomy cases for which histological verification was not possible were excluded. There were 11 (of 18) colectomy cases for treatment of colitis, none of which demonstrated severe colitis. | |||
| PSC-IBD | |||
| Liver transplant | |||
| No | 10 | 26 | 0.60 |
| Yes | 9 (47) | 32 (55) | |
| CholangioCa | 0 | 3 | 1.0 |
| Extensive colitis | |||
| No | 0 | 1 | 0.54 |
| Yes | 19 (100) | 51 (98) | |
| Immunosuppression | |||
| No | 16 | 47 | 0.86 |
| Yes | 3 (16) | 10 (17) | |
| Immunosuppression or colectomy for colitis* | |||
| No | 14 | 33 | 0.38 |
| Yes | 4 (29) | 19 (36) | |
| All colectomy | |||
| No | 13 | 39 | 0.92 |
| Yes | 6 (32) | 19 (33) | |
| High grade dysplasia | 2 | 1 | |
| Colorectal cancer | 1 | 3 | |
| Total | 3 (16) | 4 (7) | 0.35 |
| Pure PSC | |||
| Liver transplant | |||
| No | 2 | 4 | 1.0 |
| Yes | 2 (50) | 4 (50) | |
| CholangioCa | 0 | 0 | |
| All PSC | |||
| Liver transplant | |||
| No | 12 | 30 | 0.75 |
| Yes | 11 (48) | 36 (55) | |
| CholangioCa | 0 (0) | 3 (5) | 0.57 |